多重睡眠障碍与帕金森病患者的冷漠有关
Jolynn Jones1, Spencer A Nielson2, Jonathan Trout3
1Brigham Young University, Department of Psychology, USA.
Heliyon
|August 22, 2024
概括
失眠和白天嗜睡等睡眠障碍与帕金森病 (PD) 中的冷漠有关. 这些关联在PD患者中比对照患者强,但可能受到焦虑和抑郁的影响.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 众所周知,帕金森病 (PD) 会导致睡眠障碍和冷漠.
- 在PD中的冷漠与REM睡眠行为障碍和过度的白天嗜睡有关.
- 其他睡眠障碍与PD无动于衷之间的关系需要进一步研究.
研究的目的:
- 探索不同睡眠障碍与具有特异性PD的个体的冷漠之间的联系.
- 为了比较PD患者与匹配对照中的这些关联.
主要方法:
- 50名患有PD的个人和48名匹配的对照 (MC) 参与了这项研究.
- 通过使用多个验证的问卷 (ISI,PSQI,PROMIS-SD,ESS,PROMIS-SRI,RBDSQ) 来评估睡眠障碍.
- 使用冷漠度表 (AS) 测量了冷漠度;用STAI和BDI-II评估了情绪. 统计分析包括斯皮尔曼相关性和回归模型.
主要成果:
- 在PD组中,冷漠度评分与睡眠障碍指标有显著的相关性,特别是PROMIS-SRI.
- 在所有参与者,MC和PD组中,冷漠性子表现出与睡眠障碍有显著的相关性.
- 睡眠和冷漠之间的相关性在PD组与MC组相比显著更强,尽管这些差异在考虑焦虑和抑郁时减少了.
结论:
- 睡眠障碍,包括失眠严重程度,睡眠质量差和白天嗜睡,与帕金森病的冷漠有关.
- 这些关联是PD组特有的,在匹配的对照中没有观察到.
- 焦虑和抑郁症可能在PD的睡眠冷漠性联系中发挥作用,因此需要进一步研究潜在机制.
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