肌肉质量动态与肝硬化患者的长期肝脏相关死亡率独立相关
Jiarui Zheng1, Shuo Yang2, Wenhui Ren3
1Department of Hepatology, Peking University Hepatology Institute, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, 100044, China.
Heliyon
|August 22, 2024
概括
骨肌量 (LSMM) 的损失显著增加肝硬化患者的肝脏相关死亡风险. 监测肌肉质量可以改善患者的预后,并为临床决策提供信息.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 肌肉生理学 肌肉生理学
背景情况:
- 萨尔科佩尼亚对肝硬化预后产生负面影响.
- 在肝硬化中肌肉质量变化的临床意义尚未完全理解.
研究的目的:
- 为了研究骨肌肉质量 (LSMM) 损失在肝硬化患者的预后影响.
- 确定LSMM是否是肝脏相关死亡率的预测因素.
主要方法:
- 对158名肝硬化患者 (2018年1月 - 2023年8月) 的回顾性分析.
- 用于评估骨肌面积和计算年度相对变化 (ΔSMA/y) 的计算机断层扫描.
- LSMM定义为 ΔSMA/y < 0;用于死亡率分析的竞争性风险模型.
主要成果:
- 95名患者 (60.1%) 患有LSMM;中位数 ΔSMA/y 是 -0.9%.
- LSMM与肝脏相关死亡率的增加显著相关 (HR1.86,p=0.047).
- 没有LSMM的患者的累积存活率明显更高 (p=0.004).
结论:
- 在肝硬化患者中,LSMM是肝脏相关死亡率的有价值预测指标.
- 骨肌肉质量的管理可以改善肝硬化患者的结果.
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