调查伊卡林的抗炎作用:综合元分析和机器学习研究
Xiaochuan Guo1,2,3, Yanqin Qin3,4, Zhenzhen Feng1,3
1Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China.
Heliyon
|August 22, 2024
概括
伊卡林及其衍生物显示出显著的抗炎作用,特别是在消化,神经,肺和尿路疾病中. 在剂量超过27.52毫克/公斤/天和治疗持续时间超过31.22天时,观察到最佳疗效.
科学领域:
- 药理学和计算机生物学
- 自然产品化学 自然产品化学
- 炎症研究 炎症研究
背景情况:
- 伊卡林是一种来自Epimedium物种的黄类物质,具有已知的抗炎性质.
- 评估伊卡林抗炎功效的临床前证据需要采取系统的方法.
- 识别由icariin调节的关键生物通路对于了解其治疗潜力至关重要.
研究的目的:
- 确定伊卡林及其衍生物抗炎作用的优越性.
- 建立一个参考框架,用于评估临床前证据,使用机器学习和元分析的结合方法.
- 识别潜在的生物途径和药物疗效的预测因素.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 中进行了系统的文献搜索.
- 使用R和STATA进行了元分析和子组分析 (物种,性别,疾病类型,剂量,持续时间).
- 机器学习模型是使用R (tidymodels) 开发的,TNF-α作为依赖变量,以确定疗效的预测因子.
主要成果:
- 包括19项涉及370只动物的研究,用于元分析和260只用于机器学习.
- 伊卡林和衍生品显著降低了TNF-α和IL-1β等炎症标志物.
- 机器学习在剂量>27.52 mg/kg/天和持续时间>31.22天时,在各种疾病类型 (呼吸道,泌尿,神经,消化) 中发现了增强的抗炎作用.
结论:
- 伊卡林及其衍生物具有强大的抗炎作用,有益于消化,神经,肺和尿路疾病.
- 最佳的治疗结果与更高的剂量和更长的治疗时间有关.
- 建议进行进一步的研究,包括有针对性的动物实验和安全性评估,以进行全面的临床前验证.
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