相关实验视频

Updated: Jun 15, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

IL1RL2与膀癌的表达和预后有关

Xuemei Ha^1,2, Yue Li³, Zihui Gao^1,2

¹Department of Pathology, Peking University First Hospital-Miyun Hospital, Beijing 100034, P.R. China.

Molecular and clinical oncology

|August 22, 2024

概括

介质素1受体类似2 (IL1RL2) 在膀癌 (BLCA) 中表达高,与预后不佳有关. 本研究探讨了IL1RL2的研究.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

在各种瘤中观察到interleukin 1受体类似2 (IL1RL2) 表达,但其在膀癌 (BLCA) 中的功能尚不清楚.
研究IL1RL2的作用对于理解BLCA进展和识别潜在的预后标志物至关重要.

研究的目的:

评估IL1RL2在膀癌 (BLCA) 的预后意义.
探索IL1RL2表达和BLCA中的临床病理特征之间的关联.
阐明在BLCA中涉及IL1RL2的潜在生物功能和途径.

主要方法:

利用癌症基因组图谱 (TCGA) 数据库在BLCA中进行IL1RL2表达分析.
通过逆转录-定量聚合酶链反应和西部抹杀验证IL1RL2表达.
在瘤和正常标本上进行免疫组织化学,共同表达网络分析,功能丰富和蛋白质-蛋白质相互作用网络构建.

主要成果:

IL1RL2在BLCA组织和细胞中显著表达,具有诊断潜力.
在BLCA患者中,IL1RL2表达成为总生存期 (OS) 的独立风险因素.
高IL1RL2表达与晚期,更高等级,淋巴结转移和更差的预后相关.

结论:

IL1RL2表达是膀癌 (BLCA) 的显著预后指标.
IL1RL2可能通过MAPK信号通路调节瘤进展.
IL1RL2与临床特征的关联突出了其作为BLCA治疗点的潜力.

关键词:

膀癌:膀癌是一种癌症.互联素-1受体类似的2 标记标记标记标记标记标记预后预后预后

更多相关视频

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...