治疗慢性缩性胃炎:根据现实世界TCM电子医疗记录识别子群
Yu-Man Wang1, Jian-Hui Sun2,3, Run-Xue Sun2,3
1Graduate School of Hebei University of Traditional Chinese Medicine, Hebei, China.
Frontiers in pharmacology
|August 22, 2024
概括
这项研究使用电子医疗记录的网络分析确定了慢性缩性胃炎 (CAG) 的不同亚型. 根据每种CAG亚型的症状概况和有效植物药物,提出了个性化治疗策略.
科学领域:
- 综合医学是一个整体医学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 慢性缩性胃炎 (CAG) 是一种普遍的,复杂的疾病,具有不同的临床表现,并使治疗复杂化.
- 了解CAG异质性对于开发个性化治疗方法至关重要.
研究的目的:
- 通过网络分析将临床CAG患者分为不同的亚型.
- 探索临床症状,传统中医 (TCM) 植物药物和个性化治疗的分子途径之间的关系.
主要方法:
- 收集和分析了CAG患者的6253个TCM电子医疗记录 (EMR).
- 构建了一个症状-患者相似性网络 (PSN),并使用社区检测来识别CAG子组.
- 利用网络药理学,基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 途径分析来关联症状,药物和分子机制.
主要成果:
- 确定了三个不同的CAG子组 (M29,M3,M0) 具有特征的表型和症状概况.
- 相关的特定症状集群与有效的TCM植物药物对每个子组.
- 揭示了每种亚型的植物药物调节的潜在治疗途径 (例如NF-κB,JAK-STAT,PI3K-Akt).
结论:
- 基于CAG患者的网络分类为个性化治疗策略提供了框架.
- 这种方法有助于理解CAG的复杂性,并且可以应用于其他慢性疾病.
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