血压对移植器官功能和移植接受者的存活时间的影响
Hyo Jeong Kim1, Kyung Won Kim2, Young Su Joo3
1Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Seoul, Republic of Korea.
概括
高静脉压 (SBP) 和随着时间的推移增加的SBP增加了移植 (KT) 的风险. 保持最佳血压对于KT患者的长期移植存活至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植 移植 移植 移植
- 心血管医学 心血管医学
背景情况:
- 对接受移植 (KT) 的人来说,最佳的血压目标还没有得到很好的定义.
- 系统性血压 (SBP) 是影响移植后移植结果的关键因素.
研究的目的:
- 调查基线,时间变化和基于轨迹的缩血压 (SBP) 和移植患者的结局之间的关联.
- 为了确定最佳的SBP水平和模式,以保持脏全移植功能和存活.
主要方法:
- 利用发现 (KNOW-KT,n=808) 和验证 (KOTRY,n=1,294) 移植接受者的队列.
- 在KT后1年分析了基线SBP,随时间变化的SBP和SBP轨迹 (下降,稳定,增加).
- 评估综合结结果,包括≥50%的EGFR下降或死亡审查的移植损失.
主要成果:
- 非常低的 (<110 mmHg) 和高的 (≥140 mmHg) 基线SBP与110-119 mmHg相比,与复合结结果的增加有关.
- 时间变化分析显示,最低和最高SBP水平的风险显著更高.
- 与稳定的轨迹相比,增加的SBP轨迹与不良脏结果的风险增加了2.26倍.
结论:
- 静脉血压水平≥140 mmHg和SBP轨迹的增加与移植受体患有移植功能障碍和衰竭的风险较高有关.
- 这些发现强调了监测和管理SBP模式的重要性,以改善长期的移植存活率.
- 结果在发现和验证队列中一致,加强了它们的临床相关性.
相关概念视频
01:18Hypertension and Regulation of Blood Pressure
2.0K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.0K
01:24Tissue Transplantation
348
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
348
01:28Factors affecting Blood pressure
3.1K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.1K