夜间的光线和肺癌风险:一个全球跨学科和时间序列研究
Runchen Wang1, Qixia Wang2, Jianfu Li1
1Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong 510120, China.
Chinese medical journal pulmonary and critical care medicine
|August 22, 2024
概括
夜间高水平的光线 (LAN) 与增加肺癌风险有关. 这项全球性研究发现,与滞后期有显著的关联,突出了LAN作为肺癌潜在的环境风险因素.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 夜间的光线 (LAN) 是全球跨学科研究的一个新兴问题.
- 研究环境暴露与非传染性疾病之间的关系至关重要.
研究的目的:
- 探索夜间照明 (LAN) 和肺癌发病率之间的暴露-延迟-反应相关性.
- 评估LAN对201个国家/地区肺癌发病率的影响.
主要方法:
- 利用了来自卫星的LAN数据和来自全球疾病负担研究 (1992-2018) 的肺癌发病率数据.
- 使用的斯皮尔曼相关性,人口加权线性回归和分布式滞后非线性模型 (DLNM).
- 针对社会人口统计指数和吸烟率的调整分析.
主要成果:
- 在LAN暴露和肺癌发病率之间观察到显著的正相关性.
- DLNM表明,在LAN暴露8.6时,肺癌的最大相对风险为1.05,在调整后的滞后时间为2.4年.
- 暴露于LAN显示出与增加肺癌发病率的统计学上显著关联.
结论:
- 夜间暴露于强光 (LAN) 与肺癌发病率的增加有关.
- 确定的滞后期表明LAN暴露和肺癌发展之间存在时间关系.
- 这项集团级研究提供了一种可扩展的方法来识别环境风险因素.
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