针对发网络的治疗方法
Jenna Langbein1, Ujwal Boddeti1,2, Matthew Kreinbrink1
1Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States.
Frontiers in network physiology
|August 22, 2024
概括
耐药性 (DRE) 影响全球数百万人. 针对病理发作网络,而不仅仅是焦点,可能会改善DRE患者的外科治疗结果.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 是一种常见的神经系统疾病,影响全球超过6500万人.
- 很大一部分患者 (超过三分之一) 患有耐药性 (DRE),尽管服用抗发作药物 (ASM).
- 目前对DRE的手术干预仅取得了有限的成功,超过50%的患者在手术后经历了耐药性发作.
研究的目的:
- 审查目前的手术治疗策略.
- 探索手术治疗失败的假设机制.
- 讨论网络理论在改善外科手术结果方面的潜力.
主要方法:
- 这项研究对现有关于手术管理的文献进行了叙事性审查.
- 它检查了当前的手术干预及其假设的失败机制.
- 突出显示了支持病态网络的证据.
主要成果:
- 手术中的治疗失败可能源于仅针对焦点区域而不是整个病理发作网络.
- 正在出现一种理解作为网络障碍的转变.
- 当前的外科手术方法可能无法充分解决复杂的网络动态.
结论:
- 的网络理论为手术管理提供了一个新的框架.
- 针对发作网络,而不是孤立的焦点,可能会导致更好的发作控制.
- 将手术实践和神经调节干预措施适应目标网络可能为DRE提供新的治疗策略.
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