长期低分子量肝素治疗后机械大动脉的晚期功能障碍:一个病例报告
Aye Mon1, Selvaraj Shanmuganathan2, Akhlaque Uddin1
1Department of Cardiology, Trent Cardiac Center, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK.
European heart journal. Case reports
|August 22, 2024
概括
长期低分子量肝素 (LMWH) 在有机动动脉的患者中使用可能导致门功能障碍. 建议对这些患者监测抗Xa水平,以预防并发症.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 维生素K对抗剂是机械心脏门的标准长期抗凝药.
- 并发症包括出血,血栓栓塞,以及难以监测国际正常化比率.
研究的目的:
- 报告一个晚期机械大动脉功能障碍的病例.
- 讨论长期LMWH在患有机械心脏门的患者中使用的影响.
主要方法:
- 一个66岁的男性患者的病例报告,他进行了机械大动脉置换.
- 对患者病史的审查,包括因华法林并发症而经过12年的埃诺沙巴林治疗.
- 诊断工作包括心声回声,光镜和心脏CT.
主要成果:
- 患者经历了反复发生的血栓栓塞事件,尽管治疗性埃诺沙巴林剂量.
- 机械主动脉功能障碍与一个不动的小册子和pannus被诊断出.
- 患者需要重复大动脉生物假体门手术,因为未分离的肝素没有改善.
结论:
- 长期的LMWH治疗可能与机械大动脉功能障碍有关.
- 在这些患者长期使用LMWH处方时,建议对抗Xa因子进行监测.
- 可能需要使用替代的抗凝策略或更密切的监测.
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