Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Bidirectional Disulfide Metathesis Enables Recycling of High-Performance Thermoset Networks.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Phonon Transport Mechanism of Strain-Enhanced Lattice Thermal Conductivity in Penta-NiAs<sub>2</sub> Monolayer.

Nanomaterials (Basel, Switzerland)·2026

Same author

Pharmacovigilance analysis of severe cutaneous adverse reactions associated with antiseizure medications: a FAERS database study with time-to-onset evaluation.

Frontiers in pharmacology·2026

Same author

Tunable and Selective Doping Modulation in Pd-Filled Carbon Nanotube Transistors.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Comparison of Allo-HSCT outcomes after CAR-T therapy versus chemotherapy in pediatric patients with relapsed/refractory B-ALL: a retrospective study.

The oncologist·2026

Same author

Research on Density Prediction of Laser Powder Bed Fusion Process Parameters for IN718 Nickel-Based Superalloy Based on Machine Learning.

Materials (Basel, Switzerland)·2026

Search research articles

相关实验视频

Updated: Jun 15, 2025

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

具有可切换生物功能的非平衡分散组件.

Peng Zhao¹, Yuanfeng Zhao¹, Yan Lu¹

¹School of Physical Science and Technology &, State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, 201210, Shanghai, China.

Angewandte Chemie (International ed. in English)

|August 22, 2024

概括

研究人员开发了一种新型的细胞膜样消散组件 (DSA) 系统,使用了性超分子. 这种以燃料驱动的系统模仿生物功能,使可编程的转换能够增强纤维细胞相互作用和高效,可回收的药物输送.

关键词:

消耗性自我组装是一种消耗性自我组装.性超分子性超分子燃料驱动的药物递送是燃料驱动的药物递送.纳米纤维-纳米圈过渡过程没有平衡的系统.

更多相关视频

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

相关实验视频

Last Updated: Jun 15, 2025

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Published on: October 6, 2019

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Automated Robotic Liquid Handling Assembly of Modular DNA Devices

Published on: December 1, 2017

科学领域:

生物材料科学生物材料科学
超分子化学超分子化学
合成生物学合成生物学

背景情况:

自然消散组件 (DSAs) 呈现出动态的,由能量驱动的功能转移,这是合成对应物中罕见的特征.
在人工系统中模拟这些生物转变对于开发先进材料至关重要.
嵌合式超分子化学为创造复杂,响应敏捷的合成组件提供了一条途径.

研究的目的:

设计一个模仿细胞膜样功能的合成消散组件 (DSA) 系统.
为了证明组件结构和生物活性中的可编程,燃料诱导的变化.
建立一种基于生物活性DSAs的新型可回收药物输送工具.

主要方法:

在平衡条件下,利用醇氨酸衍生物在平衡条件下形成奇拉性超分子M螺旋纳米纤维.
研究了这些纳米纤维与纤维细胞的相互作用,评估粘附和增殖.
引入化学燃料,诱导纳米纤维暂时转化为纳米球,用于药物输送,然后进行自我逆转.

主要成果:

状超分子纳米纤维通过立体特异性相互作用促进纤维细胞粘附和扩散.
添加化学燃料引发了从纳米纤维到纳米球的可逆转变.
纳米圈的形成促进了高效的,燃料驱动的药物输送,随后进行材料回收.

结论:

开发的类似细胞膜的DSA系统展示了可编程的功能转换能力.
这代表了一个新的,燃料驱动的药物输送车辆,具有自我回收特性.
这项研究推进了合成DSAs的生物应用,并为"活"材料铺平了道路.