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相关概念视频

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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RNA Structure01:19

RNA Structure

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The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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相关实验视频

Updated: Jun 15, 2025

mirMachine: A One-Stop Shop for Plant miRNA Annotation
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mirMachine: A One-Stop Shop for Plant miRNA Annotation

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miRVim:三维miRNA结构数据库

Vishal Kumar Sahu1, Ankita Subhadarsani Parida1,2, Amit Ranjan1

  • 1Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, (DYPBBI), Dr. D.Y. Patil Vidyapeeth (Deemed to be University), Tathawade, Pune, 411033, India.

MicroRNA (Shariqah, United Arab Emirates)
|August 22, 2024
PubMed
概括
此摘要是机器生成的。

miRVim数据库提供了关键的人类微RNA (miRNA) 结构,有助于计算药物发现和推进RNA生物学研究. 本资源解决了微RNA (miRNA) 结构数据的稀缺问题.

关键词:
在RNA折叠过程中.结构生物信息学 结构生物信息学人类miRNA结构.微RNA 3D 结构对miRNA的分子建模核酸建模模型中的核酸模型

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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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相关实验视频

Last Updated: Jun 15, 2025

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Isolation of microRNAs from Tick Ex Vivo Salivary Gland Cultures and Extracellular Vesicles
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科学领域:

  • 在RNA生物学,RNA生物学.
  • 生物信息学是一种生物信息学.
  • 药物发现 药物发现 药物发现

背景情况:

  • 微RNA (miRNA) 是关键的非编码RNA,在物种中具有不同的调节作用.
  • 全球存在6万多种miRNA,在人类中发现了1926种,影响基因表达.
  • 有限的实验miRNA结构阻碍了计算药物发现和人工智能驱动的研究.

研究的目的:

  • 开发miRVim,一个人类微RNA结构的综合数据库.
  • 为了克服由实验确定miRNA结构的稀缺性所带来的局限性.
  • 为了促进计算分析和推进基于人工智能的RNA生物学和药物发现预测.

主要方法:

  • miRVim集成了预测的二维结构 (MXFold2,CentroidFold,RNAFold) 和三维结构 (RNAComposer,3dRNA).
  • 该数据库还包括来自RCSB PDB的实验确定结构.
  • 这种方法整合了人类miRNAs的各种结构数据.

主要成果:

  • miRVim拥有13971个预测的二次和17045个预测的3DmiRNA结构.
  • 这种广泛的收藏解决了miRNA结构数据可用性的关键差距.
  • 该数据库支持用于药物发现和机器学习应用的计算分析.

结论:

  • miRVim为科学界提供了一个有价值的,公开可访问的资源.
  • 它在miRNA研究中显著推进了计算分析.
  • 该数据库促进了针对微RNA的新药发现工作.