miRVim:miRNA

Vishal Kumar Sahu1, Ankita Subhadarsani Parida1,2, Amit Ranjan1

  • 1Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, (DYPBBI), Dr. D.Y. Patil Vidyapeeth (Deemed to be University), Tathawade, Pune, 411033, India.

概括

miRVim数据库提供了关键的人类微RNA (miRNA) 结构,有助于计算药物发现和推进RNA生物学研究. 本资源解决了微RNA (miRNA) 结构数据的稀缺问题.

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MicroRNAs01:22

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RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
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Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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piRNA - Piwi-interacting RNAs

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Small interfering RNAs (siRNA)

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siRNA - Small Interfering RNAs

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