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在COVID-19疫苗接种后出现的全身毛细血管泄漏综合征
Chengjie Zhao1, Ruirui Xue1, Kaile Zhao1
1Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China.
Human vaccines & immunotherapeutics
|August 22, 2024
概括
系统性毛细血管泄漏综合征 (SCLS) 是一种罕见但严重的COVID-19疫苗不良反应. 这份对15例病例的综述强调了疫苗和SCLS之间的潜在联系,强调需要对罕见的疫苗副作用保持警.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 关键护理医学 关键护理医学
背景情况:
- COVID-19疫苗已被广泛使用,导致罕见的,严重的不良反应出现.
- 系统毛细血管泄漏综合征 (SCLS) 是一种危急的疾病,可导致肺,功能衰竭和死亡.
- SCLS难以诊断,并可能使现有的医疗状况复杂化.
研究的目的:
- 提高人们对与COVID-19疫苗相关的罕见疾病的认识,特别是SCLS.
- 总结和讨论COVID-19疫苗接种后的SCLS病例报告.
- 分析疫苗引起的SCLS的潜在机制,临床特征,诊断和治疗.
主要方法:
- 在Web of Science,PubMed和Embase进行了全面的文献搜索.
- 纳入标准集中在2024年2月19日之前由COVID-19疫苗引起的SCLS病例报告上.
- 分析了12篇文章,报告了15个SCLS个案.
主要成果:
- SCLS主要发生在Pfizer-BioNTech mRNA疫苗 (9/15例) 和第二剂疫苗 (10/15例) 后.
- 常见的临床表现包括低血压 (13/15) 和低心率 (11/15).
- 治疗涉及静脉注射液体 (9/15) 和皮质类固醇 (9/15),有11名患者康复,4人死亡.
结论:
- 炎症和内皮细胞损伤是将COVID-19疫苗与SCLS联系起来的潜在机制.
- 这些发现强调了监测COVID-19疫苗的严重不良反应的重要性.
- 鉴于这些罕见但严重的事件,迫切需要重新考虑COVID-19疫苗安全概况.
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