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Updated: May 7, 2026

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利用AfDesign开发一种小分子抑制剂来抑制PICK 1-PDZ

Emily Hendrix1, Xinyu Xia1, Amy O Stevens1

  • 1Department of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, USA.

Current protein & peptide science
|August 22, 2024
PubMed
概括

一个新的计算工具AfDesign可以生成有效的干,以PICK1 PDZ域为目标. 这种蛋白质-蛋白质相互作用抑制剂的设计显示了神经系统疾病药物发现的前景.

关键词:
在 AfDesign 的设计.阿尔法折叠是什么意思阿尔法折叠科拉布 折叠这是一个PDZ.一个PICK1的选择.抑制剂抑制剂的使用

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