腹腔外科手术后心上脂肪组织的开放式MRI扫描仪评估:试点研究
Carmela Asteria1, Francesco Secchi2,3,4, Lelio Morricone5
1National Institute of Obesity Cure (INCO)-Bariatric Unit, IRCCS, Policlinico San Donato, Piazza Edmondo Malan, 2, 20097, San Donato Milanese, Milan, Italy.
Endocrine, metabolic & immune disorders drug targets
|August 22, 2024
概括
腹腔外科手术显著减少心上脂肪组织 (EAT) 的体积,这是心脏风险因素. 通过MRI测量这种减少,改善了腹患者的心脏代谢预后.
科学领域:
- 心脏病学 心脏病学
- 代谢手术 代谢手术
- 放射学 放射学是一门学科.
背景情况:
- 心脂肪组织 (EAT) 被认为是心脏风险因素.
- 针对心脏脂肪组织的策略越来越感兴趣.
- 腹和代谢手术 (BMS) 是一种潜在的干预措施.
研究的目的:
- 为了评估BMS诱导的体重减轻对EAT体积的影响.
- 评估BMS后其他心脏形态功能参数的变化.
主要方法:
- 15名肥胖症患者 (有或没有代谢综合征) 接受了MRI.
- EAT体积,内脏脂肪组织 (VAT) 厚度在基线和BMS后12个月被测量.
- 患者接受了腹腔镜袖子胃切除术 (LSG) 或Roux-en-Y胃绕道术 (RYGBP).
主要成果:
- 在BMS后12个月的所有患者中,EAT体积显著下降 (心径: 91.6至67.1厘米3,心径: 89.4至68.2厘米3).
- 在代谢综合征 (MS) 和没有MS (wMS) 组中都观察到显著的EAT减少.
- 在EAT损失和BMI和VAT的减少之间发现了正相关性.
结论:
- 减少EAT是改善肥胖症患者心脏代谢预后的关键因素.
- 这项研究是第一个使用开孔MRI扫描仪进行EAT体积测量的研究.
- BMS有效地减少了EAT,突出了其治疗潜力.
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