大肠炎期间的蛋白质溶解细菌扩张通过PAR2外部域的裂变放大了炎症

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Updated: Jun 15, 2025

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Liam Emile Rondeau1, Bruna Barbosa Da Luz1, Alba Santiago1

  • 1Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.

Gut microbes
|August 22, 2024
PubMed
概括

肠道细菌的蛋白酶活性通过激活蛋白酶激活受体2 (PAR2) 来加剧炎症性肠病 (IBD). 阻止这种细菌PAR2激活可能为IBD提供新的治疗方法.

关键词:
DSS引起的结肠炎炎症性肠病是一种炎症性肠病.大肠炎是一种大肠炎.在 gnotobiotic 小鼠 中.这是一种炎症炎症炎症炎症.我们的微生物群.蛋白酶激活受体2 (PAR2) 是一个受体.蛋白质酶是一种蛋白质酶.蛋白质溶解活动的蛋白质溶解活性.

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