在肥胖和2型糖尿病中循环的介质素-33水平:系统性审查和元分析
Ghalia Missous1, Nicholas Van Panhuys1
1Laboratory of Immunoregulation, Disease Modelling and Therapeutics Department, Sidra Medicine, Doha, Qatar.
American journal of physiology. Endocrinology and metabolism
|August 22, 2024
概括
这次系统性审查发现,没有足够的证据表明Interleukin-33 (IL-33) 血清水平与2型糖尿病 (T2D) 或肥胖有关. 需要进一步的研究和标准化的测量方法来澄清IL-33的情况.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
背景情况:
- 肥胖和2型糖尿病 (T2D) 是全球卫生挑战,需要新的干预措施.
- 介素-33 (IL-33),一种抗炎性细胞因子,调节新陈代谢,是这些疾病的潜在生物标志物.
研究的目的:
- 系统地审查和元分析IL-33在肥胖和T2D中的作用.
- 评估IL-33作为疾病进展预测生物标志物的潜力.
主要方法:
- 在Scopus,科学网络和PubMed上进行系统的文献搜索,截至2023年5月30日.
- 包括的研究的质量和偏见评估.
- 分析比较T2D/肥胖组中的IL-33水平与健康对照组 (HC).
主要成果:
- 九项研究有资格进行元分析,显示没有足够的证据表明T2D与HC (MD = -79.95) 或肥胖与HC (MD = -7.31) 的显著IL-33水平差异.
- 在这两项元分析中都观察到实质性的异质性 (I2 = 97.1%和86.2%).
- 发现了与IL-33血清水平的潜在性别关联,需要进一步调查.
结论:
- 目前的证据不足以确定IL-33血清水平与T2D或肥胖之间存在显著联系.
- 改善IL-33测量标准化对于减少异质性和增强理解至关重要.
- 需要进一步的大规模研究来澄清IL-33在代谢性疾病中的作用和治疗潜力.
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