肥胖对产前阴道环境和细菌微生物群的影响:对出生结果的影响
Kelly Ingram1, Embelle Ngalame Eko2, Jaclyn Nunziato1,2
1Virginia Tech Carilion School of Medicine, Roanoke, Virginia, USA.
Journal of medical microbiology
|August 22, 2024
概括
肥胖的孕妇具有更高的阴道pH值和细菌多样性,可能增加怀孕并发症的风险. 早期检测特定的细菌,如Peptoniphilus和Anaerococcus可以预测结果.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究的研究.
- 产科 产科 产科 产科 产科
背景情况:
- 乳酸菌种通过产生乳酸来维持具有酸性pH值 (<4.5) 的阴道健康.
- 雌激素影响阴道糖原,支持乳酸菌并抑制其他细菌.
- 怀孕期间的肥胖可能会改变阴道环境,可能导致失生症和不良结果.
研究的目的:
- 为了调查超重和肥胖的孕妇是否表现出较低的雌激素和糖原水平,更高的阴道pH值和更大的阴道微生物群多样性.
- 为了确定潜在的早期怀孕预测者在高风险人群中不利的怀孕结果.
主要方法:
- 从67名孕妇 (健康体重,超重,肥胖) 收集了妊娠期间的阴道样本.
- 测量阴道pH值,糖原丰富度和微生物组合 (16SrRNA测序).
- 在怀孕10-14周时量化血清雌激素水平.
主要成果:
- 与健康体重相比,肥胖的参与者阴道pH值显著更高 (P<0.001) 和细菌α多样性更大 (P=0.033).
- 在肥胖的参与者中,阴道糖原水平随着时间的推移而增加 (P=0.033).
- 在超重/肥胖和10-14周的并发症怀孕中观察到佩普托尼菲勒斯和阿纳洛科克的相对丰度增加.
结论:
- 在肥胖的孕妇中,阴道pH值升高和微生物群多样性可能表明患有失生症.
- 在怀孕早期发现的特定的阴道细菌,如Peptoniphilus和Anaerococcus,可以作为预测怀孕结果的生物标志物.
- 进一步的研究可以评估阴道环境,以确定有负面妊娠和分娩结果风险的妇女.
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