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瘤新陈代谢向Cu2-S纳米剂调解光热衍生的和免疫激活

He Zu¹, Yanxian Wu¹, Hezhang Meng¹

¹State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.

|August 22, 2024

概括

研究人员开发了向Cu2-S (MACuS) 纳米剂的新陈代谢,用于向癌症治疗. 这些药物诱导cuproptosis (铜诱导的细胞死亡) 和高热症,触发免疫反应以有效治疗瘤,副作用最小.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

型亡是一种新兴的细胞死亡途径,涉及将铜输送到特定的蛋白质.
目前的cuproptosis策略缺乏瘤特异性,影响正常和癌细胞.
精确的铜输送和氧化还原控制对于有效的基于cuproptosis的癌症疗法至关重要.

研究的目的:

开发新的纳米剂,用于向诱导瘤中的cuproptosis.
调查向铜输送,高热和免疫反应激活的综合效应.
在临床前乳腺癌模型中评估这些纳米剂的治疗疗效.

主要方法:

葡萄糖介导生物矿物化被用于合成以Cu2-S (MACuS) 纳米剂为目标的代谢.
MACuS纳米剂通过葡萄糖载体1准瘤.
接近红外线II (NIR-II) 辐射被用于诱导高热和增强cuproptosis和反应性氧物种 (ROS) 产生.

主要成果:

在NIR-II照射后,MACuS纳米剂证明了特定的瘤向和增强型亡.
联合疗法诱导了免疫细胞死亡,触发了全身抗瘤免疫反应.
在小鼠和子乳腺癌模型中观察到显著抑制瘤生长,转移和复发.

结论:

MACuS纳米剂为癌症治疗提供精确的细胞内输送和铜的氧化还原控制.
这种方法结合了高热度,增强的cuproptosis和免疫激活,具有强大的抗瘤作用.
MACuS纳米剂显示出开发高效和特定的基于cuproptosis的瘤治疗方法的巨大潜力,降低了目标外毒性.

关键词:

的 Cu2−xS 纳米剂.这就是cuproptosis.免疫激活系统的激活光热的光热系统瘤向向向的目标

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