[对过敏性鼻炎的合理组合药物治疗的现代方法]
S K Zyryanov1,2, A V Vozzhaev1
1Patrice Lumumba Peoples' Friendship University of Russia, Moscow, Russia.
Vestnik otorinolaringologii
|August 22, 2024
概括
优化过敏性鼻炎 (AR) 治疗对于改善患者生活质量至关重要. 本综述探讨了组合疗法,如鼻内皮质类固醇与白血受体对抗剂,用于管理中度至重度的AR和相关疾病.
科学领域:
- 过敏学和免疫学
- 药理学 药理学是指药理学的学科.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 过敏性鼻炎 (AR) 显著损害生活质量,导致疲劳,情绪变化和认知问题.
- 许多患者出现中度至重度的AR,通常对初始单一疗法反应不足.
- 在临床实践中,优化AR的组合药物治疗越来越重要.
研究的目的:
- 在当前的AR管理策略中分析联合药物治疗的机会.
- 评估将鼻内皮质类固醇与白血受体对抗剂结合用于AR的好处.
- 探索AR的替代组合疗法,包括固定的组合,并讨论药物互换性.
主要方法:
- 审查当前文献和药物药理性质的药物.
- 对AR的组合治疗策略的分析,包括特定药物示例.
- 讨论替代治疗方法以及品牌和仿制药的可互换性.
主要成果:
- 联合使用mometasone furoate (鼻内皮质类固醇) 和montelukast (白三烯受体对抗剂) 显示对AR有优势,特别是在喘或慢性鼻炎等并发症中.
- 使用蒙特卢卡斯特和第二代抗组胺剂 (如利沃提里津) 的联合疗法,提供了一个替代方案,当鼻内皮质类固醇是不可行的.
- 品牌和通用AR药物的可互换性缺乏足够的研究来证明治疗等价性.
结论:
- 组合疗法,特别是用鼻内皮质类固醇和白血受体对抗剂,是优化AR治疗的有希望的策略.
- 替代组合和固定剂量配方为AR管理提供了有价值的选择,特别是在复杂的情况下.
- 需要进一步的研究来确定仿制药与品牌药物的治疗等价性,以治疗AR.
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