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个人被动采样和嫌疑人查方法突出了化学暴露中的性别差异

Nicholas J Herkert¹, Gordon J Getzinger², Kate Hoffman¹

¹Nicholas School of the Environment, Duke University, Durham, North Carolina 27710, United States.

Environmental science & technology

|August 22, 2024

概括

腕带采样器提供了具有成本效益的人类暴露评估. 一个新的R工作流程增强了腕带样本中的化学识别,揭示个人护理产品是性别暴露差异的关键驱动因素.

科学领域:

环境科学环境科学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

腕带个人采样器提供了可扩展和具有成本效益的人类暴露评估.
使用腕带进行的非目标分析扩大了对环境暴露组的理解.

研究的目的:

开发和验证一个定制的R工作流程,用于对嫌疑人进行查和对腕带样本进行化学注释.
使用气体染色学高分辨率质谱法 (GC-HRMS) 进行全面的暴露监测.

主要方法:

在R中开发了一个脚本工作流程,用于特征选择和化学注释.
方法包括空白减去,内部标准规范化和PubChem元数据利用.
工作流的验证与之前的腕带研究中的104个目标分析结果相比.

主要成果:

在QC矩阵中达到62%的真实阳性率,在腕带样本中达到48%.
在女性佩戴的腕带中发现的458个特征显著高于男性佩戴的腕带中的21个特征.
暂定识别表明个人护理产品驱动观察到的基于性别的暴露差异.

结论:

开发的R工作流有效地注释了手腕带样本中的化学特征.
性别之间存在化学物质暴露的显著差异,主要与个人护理产品有关.
腕带采样与先进的分析工作流相结合,为人类暴露组提供了强大的洞察力.

关键词:

暴露于化学物质中的化学物质暴露.显露体显露体显露体个人样本个人样本.嫌疑人的选选嫌疑人的选腕带腕带腕带

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