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Noncovalent Attractions in Biomolecules

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...

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Updated: Jun 15, 2025

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels

Published on: December 6, 2012

在共价适应型酸水凝中的细胞材料相互作用.

Shivani Desai¹, Benjamin Carberry², Kristi S Anseth²

¹Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, Pennsylvania 18015, United States.

ACS biomaterials science & engineering

|August 22, 2024

概括

此摘要是机器生成的。

联适应性网络 (CAN) 模仿细胞外基质进行细胞传递. 来自人类介质干细胞的细胞骨张力驱动了支架退化,这对组织再生至关重要.

关键词:

通过细胞介导的降解.可以注射的脚手架.多个粒子跟踪微观学微观学.铁网络的铁网络是指铁网络.

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Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

Published on: August 4, 2017

相关实验视频

Last Updated: Jun 15, 2025

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels

Generation and Recovery of β-cell Spheroids From Step-growth PEG-peptide Hydrogels

Published on: December 6, 2012

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications

Published on: September 15, 2017

Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

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Published on: August 4, 2017

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
细胞生物学细胞生物学

背景情况:

共价适应网络 (CAN) 是具有刺激响应交叉链接的动态聚合物材料.
CANs可以模仿本地细胞外基质 (ECM) 的粘弹性特性.
在再生医学中,这种仿生技术对于促进细胞迁移,增殖和分娩至关重要.

研究的目的:

以其作为可注射细胞输送载体的有效性来表征基基CANs.
研究细胞骨张力在这些网络的细胞介导降解中的作用.
为提高组织再生和细胞输送应用程序的CAN合理设计提供信息.

主要方法:

采用散装类风湿学来评估酸CANs的机械特性和应变恢复.
多重粒子跟踪微观生物学 (MPT) 用于测量封装细胞周围的细胞介导重塑和降解.
用blebbistatin抑制细胞骨张力,可以隔离酶降解途径.

主要成果:

在高应变后,Thioester CANs表现出强大的风湿性质恢复,模仿可注射材料的特性.
封装的人类介质干细胞 (hMSCs) 在大约4天内降解了CANs.
抑制细胞骨张力显著降低了周细胞降解,改变了细胞形态和运动性.

结论:

细胞骨紧张是 thioester CANs 中hMSC 介导的降解的主要驱动因素.
细胞机械力量在这些适应性网络的改造和崩中发挥着至关重要的作用.
了解这些细胞矩阵相互作用是优化CANs的关键,以获得成功的细胞递送和组织再生.