年龄和更年期状态在异常性小结节下小结节狭窄症
Andrew S Awadallah1, Andrew J Bowen2, Hawa M Ali3
1Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, U.S.A.
The Laryngoscope
|August 22, 2024
概括
年龄较大和避孕药的使用与手术后异常性小囊狭窄症 (iSGS) 患者的复发率较低有关. 这表明一种保护作用,可能是由于荷尔蒙因素.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 喉腔病理学 喉腔病理学
- 外科手术的结果
背景情况:
- 异常性小结节狭窄症 (iSGS) 是一种罕见的影响呼吸道的疾病.
- 了解影响疾病复发的因素对于患者管理至关重要.
- 之前的研究还没有广泛探讨年龄对iSGS术后复发的影响.
研究的目的:
- 为了调查患者年龄和疾病复发之间的关系,在异常性亚结节狭窄症 (iSGS).
- 评估年龄和荷尔蒙因素对iSGS复发的潜在保护作用.
- 确定可能预测iSGS患者复发风险的人口因素.
主要方法:
- 在没有先前手术的情况下进行激光切除的85名女性iSGS患者的回顾性图表审查.
- 使用Kaplan-Meier方法来估计没有复发的生存率.
- 考克斯比例危险模型被用来评估年龄和复发风险之间的关联.
主要成果:
- 在年龄和iSGS复发之间发现了统计学上显著的反向关系 (每年5%的风险降低).
- 与65岁以上的患者相比,35岁以下的患者复发的可能性几乎是65岁以上患者的10倍.
- 使用荷尔蒙避孕药的女性患者显示,复发风险降低了74%.
结论:
- 这项研究是首次报告 iSGS患者手术后年龄和疾病复发之间的逆相关性.
- 随着年龄的增长和荷尔蒙避孕药的使用,似乎可以提供对iSGS复发的保护作用.
- 这些发现表明,降低雌激素水平可能在减轻复发风险方面发挥作用.
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