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低温氧化机器 perfusion 影响了人类捐赠肝脏的免疫性

Marwa Elgosbi¹, Ada Sera Kurt¹, Maria-Carlota Londoño^1,2

¹Department of Inflammation Biology, Institute of Liver Studies, School of Immunology and Microbial Sciences at King's College London University and Hospital, UK.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

|August 22, 2024

概括

低温氧化机器输液 (HOPE) 通过减少免疫细胞透和促进调节性T细胞来减少肝移植并发症,从而导致较低的异体移植排斥.

科学领域:

移植免疫学移植免疫学
器官保存技术器官保存技术
机器 perfusion 技术机器 perfusion 技术机器 perfusion 技术机器 perfusion 技术机器 perfusion 技术机器 perfusion 技术机器 perfusion 技术

背景情况:

低温氧化机器输液 (HOPE) 是一种用于保存移植器官的策略.
在动物模型中,HOPE已经显示出降低移植后免疫反应的潜力.
关于HOPE对所有免疫力的影响的人类数据有限.

研究的目的:

为了研究HOPE对肝脏全移植和人类肝脏移植中的免疫反应的影响.
在免疫细胞形状和分子变化方面,将HOPE与静态冷藏相比较.
探索希望可以减少拒绝的机制.

主要方法:

在两个随机对照试验中,27名接受肝移植的患者.
对HOPE (14名患者) 和静态冷藏 (13名患者) 的比较.
分析不同时间点的肝脏透物,肝脏组织转录组和循环免疫细胞 (T细胞).

主要成果:

与静态冷藏相比,HOPE治疗导致输液体中的肝脏内免疫细胞减少.
希望影响了肝脏全移植中的反应性氧物种通路.
希望接受者显示调节性T细胞 (CD4+FOXP3+CD127lo) 和供体特异性调节性T细胞增加,CD8+T细胞全活性降低.

结论:

HOPE影响肝脏缺血-再输液损伤,并调节供体特异性T细胞反应.
结果提供了对HOPE降低异种移植排斥能力的机制性见解.
通过调节免疫反应,HOPE显示了改善肝移植结果的潜力.

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