放射治疗后的低益生素水平是否可以预测下垂体病的发生?
Chiara Mele1, Stella Pigni2,3, Marina Caputo4
1Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, Novara, 28100, Italy.
Reviews in endocrine & metabolic disorders
|August 22, 2024
概括
放射治疗 (RT) 可以损害垂体腺,可能降低益生素 (PRL) 水平. 需要进一步的研究,以了解RT后的低分泌率和其代谢并发症.
科学领域:
- 内分泌学 在内分泌学.
- 神经瘤学神经瘤学
- 辐射瘤学 辐射瘤学
背景情况:
- 辐射疗法 (RT) 可以导致脑下垂体-垂体区域的神经毒性和血管损伤,导致神经内分泌的改变.
- 术后前垂体缺陷已经得到了充分的证据,但对前素 (PRL) 分泌的影响仍然不完全理解,文献中发现的结果各不相同.
研究的目的:
- 在接受RT的患者中调查hypopituitarism和hypoprolactinemia之间的关联.
- 为了突出低估了由于RT患者的评估和随访不足而导致的低分泌性血症.
- 强调需要基于潜在的代谢并发症在RT幸存者中诊断和管理标准的需要.
主要方法:
- 对RT诱导的垂体损伤和PRL分泌物的现有文献的综述.
- 分析研究评估脑下垂体功能后骨RT,专注于PRL水平的研究.
- 评估诊断挑战和随访局限性对于这个患者群体的hypoprolactinemia.
主要成果:
- 已经报告了PRL水平的渐进性下降,这表明放射诱导的脑垂体乳细胞受损.
- 较低的PRL水平可能与较大的垂体损伤和下丘脑功能障碍相关.
- 由于其作为一般性下垂体病的组成部分的评估以及长期跟踪不足,低血糖性血症往往被低诊断.
结论:
- 低乳糖血是头骨RT的潜在后果,需要进行系统的调查.
- 当前的诊断和随访方案可能低估了RT诱导的低分泌率的发生率和影响.
- 临床评估患有下垂体风险的患者,特别是接受RT的患者,应包括评估由于与代谢并发症相关的低分泌素血症.
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