边缘侵蚀的自然历史在手和没有骨关节炎
Hari A Sharma1, Timothy E McAlindon2, Mary B Roberts3,4
1UMass Chan Medical School, Worcester, MA, USA.
Clinical rheumatology
|August 22, 2024
概括
边缘侵蚀 (ME) 与中心侵蚀 (CE) 不同,主要影响没有骨关节炎的关节中的男性. MEs可以预测放射性进展,但不能预测手痛.
科学领域:
- 风湿病学和骨关节炎研究研究
- 关节疾病的放射性评估
背景情况:
- 手部骨关节炎是一种影响关节健康的常见疾病.
- 了解不同类型的侵蚀,如边缘侵蚀 (ME),对于诊断和预后至关重要.
研究的目的:
- 为了确定手部骨关节炎边缘侵蚀 (ME) 个体的特征.
- 在48个月内检查ME的变化和放射性进展.
- 在流行率和放射特征方面,将ME与中央侵蚀 (CE) 进行比较.
主要方法:
- 从骨关节炎倡议在基线和48个月手部X射线图的分析.
- 对疾病严重程度 (Kellgren-Lawrence等级) 和边缘 (MEs) 或中心侵蚀 (CEs) 的存在进行放射性评估.
- 用于描述参与者和联合级频率的描述性统计数据.
主要成果:
- 在3558名参与者中,89人发现了边缘侵蚀 (MEs),男性,老年人和吸烟者更常见.
- 与中心侵蚀 (CE) 相比,ME在没有骨关节炎的关节中发生的频率更高 (54%).
- 患有ME的关节比没有ME的关节呈现更高的放射性进展 (18%) (4%),但没有观察到与手部疼痛的关联.
结论:
- 边缘侵蚀 (MEs) 与中心侵蚀 (CE) 不同,通常出现在没有放射性关节炎的关节中.
- MEs在男性中更为普遍,并可能作为未来放射性进展的指标.
- MEs的存在与手部疼痛无关,但与随着时间的推移增加的关节严重性有关.
相关概念视频
01:27Growth of Cartilage and Bone Tissue
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
01:29Blood and Nerve Supply to the Bones
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
01:27Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:10Bones of the Lower Limb: Tibia and Fibula
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
01:10Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...