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患有免疫媒介性炎症疾病的患者对疫苗可预防感染的保护不足
Natasja van de Pol1, C Janneke van der Woude1, Marijn Vis2
1Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Infection
|August 22, 2024
概括
接受免疫抑制疗法的免疫媒介性炎症疾病 (IMID) 患者对麻疹和肺炎球菌病等可预防感染的疫苗接种率较低. 改善疫苗接种策略对于这个弱势群体至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 接受免疫抑制治疗的免疫媒介性炎症疾病 (IMID) 患者面临感染的风险增加,包括那些可以通过疫苗预防的感染.
- 评估这个人群是否遵守疫苗接种指南对于患者安全至关重要.
研究的目的:
- 评估接受全身免疫抑制治疗的IMID患者的疫苗接种状态.
- 将患者疫苗接种率与当前荷兰国家指南进行比较.
主要方法:
- 从2022年8月到2023年3月,荷兰医院的皮肤病学,风湿病学和胃肠病学部门向IMID患者分发了一项调查.
- 患者报告的疫苗接种数据被收集并根据已建立的疫苗接种协议进行分析.
主要成果:
- 达到了32% (1,905/5,987) 的应答率,最终分析包括了1,390名患者.
- 虽然92%的人遵循了荷兰国家免疫计划,但在免疫抑制之前,只有2%的人接种了针对麻疹的疫苗,4%的人接种了角膜炎/疹/脊髓灰质炎 (DT-IP) 的疫苗.
- 62%的人每年接种流感疫苗,16%的人接种肺炎球菌疫苗,91%的人完全接种了COVID-19疫苗.
结论:
- 接受免疫抑制治疗的IMID患者的疫苗接种率与当前的指导方针不一致.
- 需要有针对性的干预措施,以促进对麻疹,DT-IP,肺炎球菌和流感感染的免疫在这个患者群体.
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