绝经后的激素治疗与眼病发病的晚年相关
Kelleigh Hogan1,2,3, Xiangqin Cui1,4, Annette Giangiacomo5
1Center for Visual and Neurocognitive Rehabilitation Atlanta VA Medical Center Atlanta, GA, United States.
Investigative ophthalmology & visual science
|August 22, 2024
概括
绝经后妇女使用荷尔蒙疗法 (HT) 与晚期青光斑诊断有关. 较长的HT持续时间与延迟发病相关,这表明雌激素在预防青光瘤方面具有保护作用.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 玻璃眼是全球不可逆转的失明的主要原因.
- 荷尔蒙疗法 (HT) 已被假设影响玻璃眼风险.
- 了解影响绝经后妇女青光眼发病的因素对于公共卫生至关重要.
研究的目的:
- 调查激素治疗 (HT) 使用与绝经后妇女青光眼诊断年龄之间的关联.
- 为了确定HT的使用是否延迟了开角玻璃眼的出现.
- 探索HT持续时间和青光眼诊断年龄之间的关系.
主要方法:
- 仅对被诊断患有开角玻璃眼 (2000-2019年) 的女退伍军人进行了回顾性单个案例研究.
- 倾向性得分匹配用于比较HT使用者 (n=1926) 与未接受治疗的女性 (n=1026).
- 多变量线性回归分析了导致青光眼诊断的因素,包括HT持续时间和更年期年龄.
主要成果:
- 在HT使用者 (r=0.54) 和非使用者 (r=0.57) 之间观察到青光瘤诊断年龄和更年期之间的线性关系.
- HT使用者在晚年被诊断出患有玻璃眼瘤.
- 增加HT使用时间 (0-2,2-5,>5年) 与晚期青光眼诊断 (2.20,3.74,4.51年) 有显著关联.
结论:
- 较长时间使用荷尔蒙疗法与绝经后妇女晚诊眼的诊断有关.
- 对于青光眼诊断的HT的保护作用可能会受到更年期的年龄的影响.
- 这些发现表明雌激素在青光眼病原发生过程中可能起着保护作用,因此需要进一步调查.
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