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Updated: Jun 15, 2025

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免疫检查点抑制剂诱导的心脏毒性:系统性审查和元分析

Dorte Lisbet Nielsen1, Carsten Bogh Juhl2,3, Ole Haagen Nielsen4

  • 1Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

JAMA oncology
|August 22, 2024
PubMed
概括

免疫检查点抑制剂 (ICI) 可能导致心血管不良反应 (CVAE),包括心肌炎. 早期识别和及时管理至关重要,但来自随机试验的证据缺乏最佳策略.

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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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