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Updated: Jun 8, 2026

Identification of Protein Interacting Partners Using Tandem Affinity Purification
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Identification of Protein Interacting Partners Using Tandem Affinity Purification

Published on: February 25, 2012

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对14-3-3/TAZ蛋白质与蛋白质相互作用的基于片段的质疑

Blaž Andlovic1,2, Dario Valenti2,3, Federica Centorrino2

  • 1Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.

Biochemistry
|August 22, 2024
PubMed
概括

研究人员发现了一种新型分子,可以稳定14-3-3蛋白的相互作用. 这一发现为通过稳定蛋白质-蛋白质相互作用来开发向治疗提供了一个新的化学起点.

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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相关概念视频

Bacterial Protein Maturation01:26

Bacterial Protein Maturation

Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...