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平均血小板体积/血小板计数比和Dipper/非Dipper高血压患者
Serdar Gökhan Nurkoç1, Turab Yakışan1
1Department of Cardiology, Yozgat State Hospital, Yozgat, Turkey.
Angiology
|August 22, 2024
概括
平均血小板体积/血小板计数 (MPV/PC) 的比率在非浸泡型高血压患者中比浸泡型高血压患者高. 这一比率可能有助于预测高血压的非浸泡模式,表明潜在的心血管风险.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
背景情况:
- 血小板指数,如平均血小板体积 (MPV) 和血小板计数 (PC),与炎症和血小板反应性相互作用.
- 高血压管理通常涉及评估血压 (BP) 模式,如滴水和非滴水状态.
研究的目的:
- 为了研究MPV/PC比率与高血压患者的血压 (BP) 模式之间的关系.
- 为了确定MPV/PC比率是否可以预测非滴滴高血压状态.
主要方法:
- 利用24小时的门诊血压监测 (ABPM) 将720名高血压患者分为滴水和非滴水组.
- 从入院时采集的外周静脉血液样本计算了MPV/PC比.
- 用户接收机运行特征 (ROC) 曲线分析,以确定最佳的MPV/PC比率切线,用于预测非浸泡模式.
主要成果:
- 与滴水高血压患者相比,非滴水高血压患者的MPV/PC比率显著更高 (P < .001).
- 0.040的MPV/PC比被确定为预测非浸泡状态的最佳切断值 (AUC:0.726,P <.001),具有64.1%的灵敏度和64.3%的特异性.
- 临床特征在dipper和非dipper组之间是相似的.
结论:
- 该MPV/PC比率是一个潜在的生物标志物,用于识别非滴滴高血压患者.
- 升高的MPV/PC比可能与有助于增加非滴滴高血压患者心血管风险的机制有关.
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