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婴儿胃肠道微生物与产后6个月内母亲微生物群之间的关系
Menglu Li1, Yuling Xue2, Han Lu1
1College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
Microbiology spectrum
|August 22, 2024
概括
母亲的肠道微生物群显著影响婴儿的肠道微生物,而不是母乳. 分娩方式和养方式影响这种微生物转移,突出显示了母亲的健康状况.
科学领域:
- 微生物学 微生物学
- 人类微生物组 人类微生物组
- 婴儿健康 婴儿健康
背景情况:
- 母亲的肠道微生物组在生命早期塑造婴儿的肠道微生物群中起着至关重要的作用.
- 了解传播动态和影响因素对于婴儿肠道健康至关重要.
研究的目的:
- 调查母亲和婴儿肠道微生物群之间的关联.
- 量化母体微生物群对婴儿肠道微生物群的贡献.
- 探索婴儿肠道微生物群,短链脂肪酸 (SCFA) 和分泌免疫球蛋白A (sIgA) 之间的相关性.
主要方法:
- 16S rRNA基因测序用于婴儿便,母亲便和母乳中的微生物群分析.
- 快速预期-最大化微生物源追踪 (FEMS) 微生物源归因.
- 气相色谱和ELISA用于SCFA和婴儿便中的sIgA量化.
主要成果:
- 孕产妇的肠道微生物群对婴儿的肠道微生物群的贡献更大 (43.58%±11.13%),而不是母乳微生物群.
- 婴儿肠道微生物群的组成,包括蛋白质细菌,与之前的发现不同.
- 酸与*Megasphaera*正相关,而sIgA与*Bacteroides*正相关,与*Klebsiella*和*Clostridium_XVIII*负相关.
结论:
- 孕产妇的肠道健康是建立和维持婴儿肠道微生物群的关键.
- 分娩方式和养习惯显著影响母亲对婴儿的微生物贡献.
- 研究结果支持针对性干预,以优化早期婴儿肠道健康.
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