基因型的RhD+红细胞用于D阳性患有状细胞病的D阳性患者,具有传统的RHD和意外的抗D红细胞
Stella T Chou1,2, Julia Mewha1, David F Friedman1,2
1Division of Hematology, Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, PA.
Blood
|August 22, 2024
概括
具有抗D的D阳性患者可以安全地接受D阳性输血. 这项研究表明,RHD基因定型可以指导输血,减少对罕见的D阴性血型的依赖.
科学领域:
- 输血医学 输血医学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 在D阳性个体中,可能会发生意想不到的抗D与免疫接种,特别是那些接受黑人献血者血液的状细胞病患者.
- 患有抗D的患者通常需要终身输血,用D阴性 (Rh阴性) 血液,压力库存.
- 这种做法增加了对Rh阴性单元的需求,特别是对于长期输血患者.
研究的目的:
- 为了确定患有抗D的D阳性患者是否可以安全地接受D阳性输血.
- 评估使用来自黑人捐赠者的RHD基因型匹配单位的可行性.
- 在这种情况下,评估抗D重现和红细胞存活率.
主要方法:
- 五名经历慢性红细胞交换的患者接受了D阳性单位的输血.
- 单位是RHD基因型,输血逐渐增加.
- 患者被监测到抗D复兴和红细胞存活率.
主要成果:
- 在输血72个D阳性RHD基因型单位后,任何患者都没有发生抗D再刺激.
- 红细胞存活率没有受到影响.
- 确定了意想不到的抗C和抗E,与捐赠者的变异RHCE等位基因有关.
结论:
- 具有抗D和常规RHD基因型的D阳性患者可以安全地输血D阳性,RHD基因型单位.
- 捐赠单位的RH基因定型可以优化黑人捐赠单位的使用.
- 这一策略可能会减少对Rh阴性血液制品的需求.
相关概念视频
01:19Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K
01:10Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
02:45Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
02:20Blood Types
17.5K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.5K
01:49Multiple Allele Traits
34.1K
The Concept of Multiple Allelism
34.1K