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Updated: Jun 15, 2025

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通过DOT1L介导的RAP80甲基化促进BRCA1的招募,以引起DNA修复

Huangqi Tang1,2, Ya-Fei Lu1, Rongsheng Zeng1

  • 1Shenzhen University International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen 518055, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 22, 2024
PubMed
概括

DOT1L甲基化RAP80,使BRCA1-A复杂的招募到DNA损伤部位成为可能. 这一过程对于癌细胞的放射治疗耐药性至关重要,并为改善放射敏感性提供治疗点.

关键词:
这就是BRCA1的原因.修复DNA损伤的修复DOT1LL 在线播放RAP80 RAP80是指80年级的一项活动.基斯顿基因基因基因基因基因基因基因基因基因基因基因基因基因基因基因

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