在美国全国代表性样本中,疼痛与大麻和烟草使用模式之间的双向关系
Dana Rubenstein1,2, Michael J Green3, Maggie M Sweitzer1
1Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States.
Pain
|August 22, 2024
概括
慢性疼痛与吸烟和大麻使用有关. 这项研究发现,疼痛强度会影响物质的使用,而物质的使用,包括大麻和烟草的共同使用,会增加疼痛的严重程度,显示出双向关系.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 药物使用研究研究 药物使用研究
背景情况:
- 慢性疼痛影响到五分之一的美国成年人,经常与增加的烟草和大麻消费一起发生.
- 虽然烟草和疼痛之间的联系是已知的,但疼痛,大麻使用和同时使用大麻和烟草之间的复杂相互作用仍未得到充分探索.
研究的目的:
- 调查物质使用 (不包括烟草,大麻和共同使用) 与疼痛强度之间的双向关系.
- 为了确定物质使用模式对中度至重度疼痛的发展或恶化的影响.
- 评估中度至严重的疼痛如何影响后续的烟草和大麻使用模式.
主要方法:
- 从人口评估烟草和健康研究 (2015-2021) 中对31,983名美国成年人的纵向分析.
- 疼痛强度被分类为没有/低疼痛 (≤4/10) 或中度/严重疼痛 (>4/10).
- 药物使用被分为不使用,专用使用 (烟草或大麻) 和共同使用,通过后勤和多项回归模型进行评估.
主要成果:
- 与没有物质使用相比,大麻和烟草的联合使用,独家烟草使用和基线独家大麻使用都与随访时中度/严重疼痛的几率增加有关.
- 在基线中,中度/严重的疼痛显著增加了随后的共同使用,独家烟草使用和独家大麻使用的几率,与没有物质使用相比.
- 在随访时,中度/严重的疼痛也增加了与独家大麻或烟草使用相比,共同使用的几率,这表明潜在的协同效应.
结论:
- 疼痛强度和单独或联合使用烟草和大麻之间存在双向关联.
- 同时使用大麻和烟草可能对疼痛严重程度产生协同影响.
- 研究结果强调需要综合方法来管理慢性疼痛和物质使用障碍.
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