探索非编码RNAs在心房隔膜缺陷发病的作用:一个系统性审查
Zahra AmiRsardari1,2,3, Akram Gholipour1, Zahra Khajali1,3
1Cardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
PloS one
|August 22, 2024
概括
非编码RNAs (ncRNAs) 在心房隔膜缺陷 (ASD) 的进展中起重要作用. 本综述强调了关键的ncRNA,为ASD生物标志物发现和治疗提供了洞察力.
科学领域:
- 心血管生物学 心血管生物学
- 分子遗传学 分子遗传学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 前庭隔膜缺陷 (ASD) 是一种常见的先天性心脏病.
- 非编码RNAs (ncRNAs) 与各种病理生理过程和疾病有关.
- 了解ncRNA在ASD病原体中的作用至关重要.
研究的目的:
- 系统地审查ncRNAs在ASD病原和进展中的参与和意义.
- 为了确定与ASD相关的特定ncRNAs.
主要方法:
- 在2023年6月19日之前,对四个主要数据库 (PubMed,Embase,Scopus,Web of Science) 进行系统搜索.
- 包括13项研究,包括874名自闭症患者,21名父母和22名孕妇.
- 使用纽卡斯尔-太华规模评估的偏差风险.
主要成果:
- 五种长ncRNAs (STX18-AS1,HOTAIR,AA709223,BX478947,Moshe) 与ASD的进展有关.
- 几种微RNA (例如hsa-miR-19a,hsa-miR-375,miR-29c,miR-143/145) 也与ASD相关.
- 这些发现与之前关于心血管疾病中ncRNAs的研究一致.
结论:
- 在理解ASD机制方面,ncRNAs是至关重要的.
- 已识别的ncRNA具有发现ASD生物标志物的潜力.
- 对ncRNA机制的进一步研究可以促进ASD治疗.
相关概念视频
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