改变了对甲状腺激素β的耐药性患者的大脑功能连接
Martin Göttlich1,2, Krishna Chatterjee3, Carla Moran3
1Institute of Medical Psychology, University of Lübeck, Lübeck, Germany.
PloS one
|August 22, 2024
概括
抗甲状腺激素β (RTHβ) 耐药的患者表现出大脑网络的改变和行为症状,反映出注意力缺陷多动性障碍 (ADHD). 这些发现表明,RTHβ和ADHD之间存在共同的神经生物学基础.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 精神病学是一种精神病学.
背景情况:
- 对甲状腺激素β (RTHβ) 的耐药性是一种罕见的遗传疾病,影响甲状腺激素的作用.
- 在RTHβ和注意力缺陷多动障碍 (ADHD) 之间的神经行为相似性需要进行调查.
- 了解这些相似之处可能会为ADHD病理生理学提供见解.
研究的目的:
- 为了研究RTHβ患者大脑网络组织的变化.
- 探索RTHβ和ADHD之间潜在的神经行为相似之处.
- 为了比较RTHβ患者和健康对照者的静止状态功能连接 (rs-fMRI) 和认知领域.
主要方法:
- 一项前性病例控制研究,涉及21名经遗传确认的RTHβ患者和21名匹配的健康对照.
- 评估ADHD症状使用成人ADHD自我报告量表 (ASRS-v1.1) 和ADHD评分量表-IV.
- 分析rs-fMRI数据,使用voxel-wise和基于Atlas的方法来识别大脑网络的变化.
主要成果:
- RTHβ患者报告了与ADHD一致的行为症状.
- 在RTHβ患者的语言和状回旋中观察到较弱的网络集成,这与与胰岛和补充运动皮层的连接性减少有关.
- 与对照组相比,在RTHβ患者中发现了默认模式网络和认知控制网络区域之间的功能连接增加.
结论:
- RTHβ与明显的脑网络变化有关,包括视觉处理区域的连接性较弱,以及改变的默认模式/认知控制网络交互.
- 这些发现支持了RTHβ和ADHD之间存在显著的神经心理相似性的观点.
- 在RTHβ中观察到的大脑连接模式可能是ADHD类症状的基础,例如分心和注意力缺陷.
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