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在临床实践中使用拉坦普洛斯0.024%眼科溶液的一年经验:一项追溯观察性研究

Chun-Mei Hsueh^1,2, Chen-Hsin Tsai^1,2, Jou-Chen Huang^1,2

¹Department of Ophthalmology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.

|August 22, 2024

概括

拉塔诺普罗斯布诺德 (LBN) 0.024%在从其他前列腺素类似物 (PGAs) 转换的开角玻璃眼患者中提供额外的眼内压力 (IOP) 降低. 虽然出现了刺激等初始副作用,但LBN在12个月内显示了持续的内压降低.

科学领域:

眼科医生眼科眼科
视光眼管理视光眼管理
药理学研究药理学研究

背景情况:

开角玻璃眼 (OAG) 需要有效的眼内压力 (IOP) 管理.
前列腺素类似物 (PGAs) 是一种常见的第一线治疗方法.
需要新的治疗药物来改善IOP控制和患者的治疗结果.

研究的目的:

为了评估0.024%的拉坦诺普罗斯布诺德 (LBN) 眼科溶液在降低IOP的临床疗效和安全性.
评估LBN作为现有PGA治疗的替代疗法的性能.
在现实世界的临床环境中分析额外的内脏压力减轻和不良影响.

主要方法:

78名OAG患者的回顾性图表审查,使用LBN 0.024%至少一年.
患者从其他PGAs转换为LBN,在1,3,6和12个月后进行随访.
关键的结果措施包括IOP,视网膜神经纤维层厚度,视野和不良事件;进行了子组分析.

主要成果:

60%的患者在12个月内继续服用LBN,在第12个月获得了额外的1.6 mm Hg (8.8%) 的内血压平均降低.
与基线PGA治疗相比,观察到显著的额外IOP降低 (P<0.0001).
可容忍的副作用包括刺激和高血压;视野或RNFL厚度没有显著变化.

结论:

在OAG患者中取代其他PGAs时,0.024%的拉塔诺普罗斯布诺德提供了统计学上显著的额外的内血压降低.
尽管最初的不良反应,但在临床实践中,LBN在12个月内表现出持续的疗效.
LBN代表了一种有价值的治疗选择,用于提高IOP控制在青光眼的管理.

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