在泰国南部的Burkholderia pseudomallei分子流行病学分析
Jedsada Kaewrakmuk1,2, Sarunyou Chusri3, Pacharapong Khrongsee4,5
1Faculty of Medical Technology, Prince of Songkla University, Songkhla, Thailand.
PLoS neglected tropical diseases
|August 22, 2024
概括
一种严重的细菌性疾病 - - 乳腺炎在泰国南部仍然存在,死亡率很高. 最近患者中发现的Burkholderia pseudomallei菌株与几十年前的环境分离物匹配,表明长期的环境持久性.
科学领域:
- 传染性疾病 传染性疾病
- 环境微生物学 环境微生物学
- 流行病学 流行病学
背景情况:
- 由Burkholderia pseudomallei引起的梅病是泰国的一个重大健康问题.
- 泰国南部经历了高的死亡率从乳腺炎,尽管较低的发病率相比东北部.
- 了解B. pseudomallei的流行病学和环境储库对于该地区的公共卫生至关重要.
研究的目的:
- 为了调查泰国南部的有机粉症的流行病学.
- 在泰国南部的自然环境中确定B. pseudomallei的存在和遗传多样性.
- 将临床分离与环境菌株相关联,以了解传播动态.
主要方法:
- 多部位序列类型 (MLST) 用于表征从2014年至2020年的263个临床B. pseudomallei分离物.
- 临床隔离物与同一地区的历史环境隔离物进行了比较.
- 在克拉省进行了环境调查,分析了土壤和水样以检测B. pseudomallei的存在.
主要成果:
- 在临床隔离物中确定了72种不同的序列类型 (ST),其中35%与历史环境隔离物相匹配.
- 在患者中经常发现特定的ST (288,84,54,289,46).
- 在25%的土壤位置和26%的水源中检测到B. pseudomallei,在各种环境中发现了积极的样本,包括农业区,草原,布和溪流.
结论:
- 泰国南部近期发生的大量梅毒病例与B. pseudomallei菌株有关,这些菌株已经在环境中存在了60多年.
- 这些发现凸显了B. pseudomallei在泰国南部的长期环境存在.
- 这项研究有助于评估东南亚地区的性疹病的区域威胁.
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