血管变化和不可逆转的并发症在120度地带使用宽域的汗水源光学一致性图谱血管图谱在Vogt-KOYANAGI-HARADA疾病中
Suo Guo1,2, Lan Xia1, Rong Hu1
1The First Affiliated Hospital of Chongqing Medical University, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, China; and.
Retina (Philadelphia, Pa.)
|August 22, 2024
概括
持续超过24个月的慢性Vogt-Koyanagi-Harada疾病 (VKH) 显示了视网膜和胆道血管密度 (VD) 和胆道体积的减少. 延长VKH持续时间和胆道VD减少与不可逆转的 fundus并发症有关.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 血管生物学 血管生物学
背景情况:
- 沃格特-科亚纳吉-哈拉达病 (VKH) 是一种影响眼组织的全身性炎症状况.
- 慢性VKH可以导致由于底部并发症导致不可逆转的视力损伤.
- 广场成像对于评估外围视网膜和胆道变化至关重要.
研究的目的:
- 用广场扫描源光学连贯断层扫描血管学 (WS-OCTA) 在休息阶段对慢性Vogt-Koyanagi-Harada疾病 (VKH) 的底部变化的特征.
- 探索 fundus 变化与 VKH 疾病中不可逆转的并发症之间的联系.
主要方法:
- 一项前性横截面研究,涉及69名慢性VKH患者和55名健康对照.
- 使用WS-OCTA来评估视网膜和胆道血管密度 (VD),胆道体积和胆道血管密度指数.
- 后勤回归分析确定了与不可逆转并发症相关的因素.
主要成果:
- 与持续时间>24个月的VKH患者相比,VKH持续时间>24个月的患者表现出显著较低的视网膜和胆道静脉损伤,胆道体积减少以及较低的胆道血管度指数.
- 疾病持续时间 (P = 0.008) 和大/中胆管VD减小 (P = 0.001) 与不可逆转的并发症有显著的相关性.
结论:
- 在静止期的慢性VKH疾病 (>24个月) 与视网膜和胆道血管和体积的更严重减少有关.
- 长时间的疾病持续时间和胆道血管的减少是VKH不可逆转的底部并发症的危险因素.
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