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在头部和部状细胞癌中DSG-2,CXADR,CD46的表达和预后

Inga Marte Charlott Seuthe¹, Lea Krause¹, Markus Ruwe²

¹Department of Otorhinolaryngology, Head and Neck Surgery, University of Witten/Herdecke, Catholic Hospital Hagen, Dreieckstraße 15, Hagen 58097, Germany.

Pathology, research and practice

|August 22, 2024

概括

腺病毒受体DSG-2,CXADR和CD46在头部和部状细胞癌 (HNSCC) 中表达,但不会影响患者的存活率. 然而,它们在晚期瘤中的表达表明了基于腺病毒载体的瘤治疗的潜力.

科学领域:

在瘤学瘤学.
病毒学病毒学
分子生物学分子生物学

背景情况:

腺病毒受体,包括desmoglein-2 (DSG-2),coxsackievirus和腺病毒受体 (CXADR) 和CD46,都涉及病毒进入.
它们在头部和部状细胞癌 (HNSCC) 中的作用以及作为治疗点的潜力仍在调查中.

研究的目的:

在HNSCC中研究DSG-2,CXADR和CD46的表达模式.
确定这些受体在临床参数和患者存活率方面的预后意义.
评估这些受体在使用腺病毒载体的向瘤治疗中的潜力.

主要方法:

对104名HNSCC患者样本 (77个口腔,27个喉) 的回顾性分析.
免疫组织化学染色被用于检测DSG-2,CXADR和CD46的表达,得分基于强度和瘤细胞阳性.
人类乳头瘤病毒 (HPV) 状态通过p16染色和HPV-PCR确定.

主要成果:

DSG-2,CXADR和CD46分别在81.7%,34.6%和57.7%的HNSCC瘤中得到表达.
高的DSG-2表达与晚期瘤大小,增加等级和HPV阳性与口腔状细胞癌 (OPSCC) 相关联.
高CXADR表达与喉平细胞癌 (LSCC) 中的阳性淋巴结状况,以及OPSCC中先进的AJCC阶段和HPV阳性有关.
在CD46表达和临床数据之间没有发现显著的相关性,DSG-2,CXADR或CD46表达也没有影响5年总体或无病生存期.

结论:

在HNSCC中DSG-2,CXADR和CD46表达没有对患者存活的预后价值.
在HNSCC中存在这些腺病毒受体表明了优化基于腺病毒载体的瘤治疗的潜力.
高度的DSG-2和CXADR表达在先进的OPSCC瘤中突出了治疗增强的具体机会.

关键词:

亚地诺病毒受体的受体是什么?CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 CD46 这就是CXADR.这就是DSG-2.头癌:头癌是一种癌症.

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