从临床孤立综合征到多发性硬化症的进展预测因素:中国的一项前性研究
Xiaohui Qiu1, Yeyuan Liang1, Yunfei Wei1
1Department of Neurology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Clinical neurology and neurosurgery
|August 22, 2024
概括
年龄较小,脑脊液 (CSF) 神经纤维光链 (NfL),IL-23和蛋白质水平升高预测中国患者从临床隔离综合征 (CIS) 到多发性硬化症 (MS) 的进展.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物标志物研究 生物标志物研究
背景情况:
- 临床隔离综合征 (CIS) 代表了多发性硬化症 (MS) 的临床前阶段.
- 预测CIS向临床确定的MS (CDMS) 的进展对于及时干预至关重要.
- 在不同的人口中,疾病进展率有很大差异.
研究的目的:
- 在中国队列中,确定从CIS到CDMS的进展预测因素.
- 研究各种临床和实验室标记物与CIS转换为CDMS的相关性.
主要方法:
- 一个单中心队列研究包括96名新诊断的CIS患者 (2018-2021).
- 患者接受了全面的临床评估,MRI和实验室测试.
- 通过2017年麦当劳标准,在至少24个月的随访期间,将CDMS的进展定义为.
主要成果:
- 在随访期间,59.38%的CIS患者进展到CDMS.
- 较年轻的发病年龄 (OR=43.43,p<0.021) 预测了进展.
- 增加的CSF蛋白质 (OR=58.64,p=0.009),CSF NfL (OR=97.00,p=0.003) 和CSF IL-23 (OR=412.02,p=0.004) 是显著的预测因素.
结论:
- 发病时年龄较小是CIS到CDMS进展的关键预测因素.
- 脑脊液中NfL,IL-23和蛋白质水平的升高是预测MS发展的潜在生物标志物.
- 这些发现提供了对中国人口早期多发性硬化症预测的见解.
相关概念视频
01:24Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
01:29Biological Causes of Schizophrenia
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
01:29Psychological and Sociocultural Causes of Schizophrenia
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
01:27Depressive Disorders: Etiology
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...