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Updated: Jun 15, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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一系列指蛋白的成员指定了不同的霍克斯染色体边界

Havva Ortabozkoyun1, Pin-Yao Huang2, Edgar Gonzalez-Buendia1

  • 1Howard Hughes Medical Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA; Howard Hughes Medical Institute, NYU Langone Health, New York, NY 10016, USA.

Molecular cell
|August 22, 2024
PubMed
概括

新的指蛋白 (ZNFs) 在发育过程中在Hox集群中建立了明显的染色质边界. 这些新型绝缘体,与凝聚素作用,调节细胞命运和定位身份,独立于CCCTC-结合因子 (CTCF).

关键词:
在CTCF中,CTCF是指CTCF.霍克斯基因在发育过程中的作用这是一个迷宫,一个迷宫.这就是PATZ1的原因.染色素的域名 染色素的域名凝聚力 在凝聚力中基因调节 基因调节 基因调节基因组组织组织绝缘的绝缘是一种绝缘.运动神经元 运动神经元指蛋白质是一种指蛋白质.

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