二十三年来使用量下降:分析德语国家药物流行病学数据集
Waldemar Greil1,2, Mateo de Bardeci2,3, Nadja Nievergelt2
1Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Germany.
Pharmacopsychiatry
|August 22, 2024
概括
在德国,奥地利和瑞士的医院,对于双相情感障碍和其他精神疾病,的处方显著下降. 这一趋势凸显了过去二十年来心理药物使用的转变.
科学领域:
- 精神病学和精神药理学精神病学和精神药理学
- 药学流行病学 药学流行病学
- 药品安全 药品安全
背景情况:
- 药物流行病学数据表明,双相情感障碍的处方下降趋势.
- 需要研究超越双相情感障碍的使用模式.
- 了解处方的长期趋势对于精神病学实践至关重要.
研究的目的:
- 检查德国,奥地利和瑞士精神病医院各种精神病诊断中的处方趋势.
- 为了比较在2001年之前和之后的不同诊断和在三个不同的时间段 (1994-2001,2002-2009,2010-2017) 中使用的.
主要方法:
- 从1994年到2017年,在精神病学药物安全计划 (AMSP) 中,分析了158,384名成年住院患者的处方数据.
- 对精神分裂症谱系障碍,情感障碍和特定诊断子组 (精神分裂症,双相情感障碍,抑郁症,复发性抑郁症,边缘性人格障碍) 的处方率的比较.
- 对不同诊断类别和时间段的处方趋势的统计分析.
主要成果:
- 在1994-2000年至2001-2017年期间,对于精神分裂谱系障碍 (7.7%至5.1%) 和情感障碍 (16.8%至9.6%) 观察到处方的显著下降.
- 对于精神分裂情绪障碍,双相情绪障碍,抑郁症,复发性抑郁症和边缘性人格障碍的处方率也显示出显著下降.
- 在双相情感障碍中的使用率从41.3%下降到31%,但在2002年后稳定下来,后期没有进一步显著的减少.
结论:
- 在多种诊断的精神病患者中,的使用显著减少,包括双相情感障碍,精神分裂症谱系障碍和其他情感和人格障碍.
- 这些发现表明,在研究期间,在精神病治疗中的处方模式发生了显著的转变.
- 与同时服用的药物通常包括奎蒂亚平,洛拉泽帕姆和奥兰扎.
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