目标试验模拟妊娠前血清维生素D状态对生育结果的影响:基于夫妇的方法
Julia D DiTosto1, Ellen C Caniglia2, Stefanie N Hinkle2
1Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Fertility and sterility
|August 22, 2024
概括
怀孕前的维生素D在双方都足够,这增加了接受不孕症治疗的夫妇活产的可能性. 维生素D状态会影响生育能力,但不会影响精液质量或怀孕流产.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养科学 营养科学
- 不孕症研究 不孕症研究
背景情况:
- 在寻求不孕症治疗的夫妇中,维生素D缺乏是常见的.
- 维生素D及其生物可用性对生育结果的作用需要进一步研究.
研究的目的:
- 评估妊娠前25-氧维生素D (25(OH) D水平和生物标志物与活产 (LB),妊娠流产和接受不孕症治疗的夫妇的精液质量之间的关联.
主要方法:
- 对一项涉及寻求不孕症治疗的夫妇的试验进行了二次分析.
- 目标试验仿真框架用于估计9个月的观察期或到怀孕之前的关联.
- 逻辑-二项式回归分析了25...OH) D状态,生物标志物和生育结果之间的关联,考虑身体质量指数.
主要成果:
- 19.5%的女性和29.9%的男性有维生素D缺乏.
- 在女性中,足够的先入为主的25(OH) D状态与28%更高的LB.的可能性有关.
- 女性和男性的维生素D不足与LB增加的可能性有关,特别是在正常的BMI个体和肥胖的女性伴侣中.
结论:
- 怀孕前的维生素D状态和生物可用性显著影响寻求不孕症治疗的夫妇的生育能力.
- 维生素D状态和活产之间的关联因体重指数而异.
- 没有发现维生素D状况与妊娠流产或精液质量之间存在显著的关联.
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