美国的抗阿兹罗密辛的mph ((A) 阳性沙门氏菌输入式血清型Typhi病毒
Kaitlin A Tagg1, Justin Y Kim2, Britton Henderson2
1Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Journal of global antimicrobial resistance
|August 22, 2024
概括
两例美国伤寒病例被确定为对关键口服抗生素阿齐思罗米耐药. 这些mph (A) 阳性沙门氏菌Typhi菌株在印度独立出现,突显了基因组监测和旅行者疫苗接种的必要性.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 美国疾病控制和预防中心 (CDC) 积极监测由沙门氏菌 (Salmonella enterica serovar Typhi (Typhi)) 引起的伤寒热.
- 在Typhi中出现的抗菌素耐药性构成了严重的公共卫生威胁,限制了治疗选择.
研究的目的:
- 通过美国基因组监测发现的第一两例mph (A) 阳性抗阿齐思罗米辛型Typhi的特征.
- 了解这些耐药菌株的遗传和流行病学特征.
主要方法:
- 通过CDC的PulseNet.使用全基因组测序进行基因组监测.
- 抗微生物敏感性测试和长读测序.
- 通过问卷和患者采访收集流行病学数据.
主要成果:
- 两名患有伤寒的相关患者曾前往印度,并感染了mph (A) 阳性亚齐胺耐药型伤寒.
- Typhi基因组属于GenoTyphi谱系4.3.1.1并且在等离子体上携带了mph(A) 基因,这表明它在印度独立出现.
- 这些菌株在遗传上与以前报告的来自巴基斯坦的mph (A) 阳性Typhi不同.
结论:
- 由对所有口服抗生素耐药的菌株引起的伤寒热是一个越来越令人担忧的问题.
- 基因组监测对于全球检测新出现的抗菌素耐药性至关重要.
- 建议对前往特有地区的旅行者进行疫苗接种,以预防伤寒.
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