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多组学揭示了红爪 (Cherax quadricarinatus) 中纳米塑料的毒性机制
Tian Zhu1, Chunxia Yao2, Shuang Hong3
1Centre for Marine and Coastal Studies, Universiti Sains Malaysia, Minden, Penang 11700, Malaysia.
The Science of the total environment
|August 22, 2024
概括
纳米塑料 (NP) 暴露导致红 (Cherax quadricarinatus) 的氧化应激和亡. 增加的NP度导致细胞损伤和代谢途径的改变,表明对水生生物有显著的毒性.
科学领域:
- 环境毒理学环境毒理学
- 水生生物学 水生生物学
- 纳米技术纳米技术
背景情况:
- 纳米塑料 (NP) 是新兴的环境污染物,可能对水生生态系统产生不利影响.
- 了解NPs在商业重要水生物种中的特定毒性机制对于风险评估至关重要.
研究的目的:
- 为了研究不同纳米塑料度对红色的影响,Cherax quadricarinatus.
- 为了阐明纳米塑料在C. quadricarinatus的肝脏中的毒性机制.
主要方法:
- 对四种纳米塑料度 (0,100,500,1000μg/L) 的C.四角的暴露.
- 使用基因病理学,转录学,代谢学和免疫光学进行分析.
- 对氧化应激标志物 (GSH,MDA) 和脂质样本 (T-CHO,TG) 的生物化学测定.
主要成果:
- 纳米塑料暴露诱导了肝中组织病变和氧化应激.
- 观察到谷氨 (GSH),甲 (MDA),总胆固醇 (T-CHO) 和甘油三 (TG) 水平的显著变化.
- 纳米塑料触发了亡途径 (caspase 3,8,9) 并影响了胆固醇代谢和胆汁分泌.
结论:
- 纳米塑料诱导Cherax quadricarinatus肝胰腺细胞中的亡和氧化应激.
- 该研究确定了水生生物体中纳米塑料毒性的关键分子机制.
- 这些发现为评估水生环境中纳米塑料风险提供了理论基础.
相关概念视频
01:36Types of Toxins
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
01:26Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:23Toxicity Testing in Animals
Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...