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富科伊丹通过促进高脂肪饮食诱导的糖尿病小鼠中TET2介导的活性DNA脱甲基化来预防糖尿病认知功能障碍
Lei Chen1, Yan Li2, Xueqian Zhang2
1School of Health and life Sciences, University of Health and Rehabilitation Sciences, China.
International journal of biological macromolecules
|August 22, 2024
概括
饮食纤维摄入量对糖尿病患者的认知功能产生积极影响. 富科伊丹是一种纤维衍生的化合物,通过改善小鼠通过TET2进行DNA脱甲基化来预防糖尿病认知功能障碍.
科学领域:
- 营养科学 营养科学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病认知功能障碍 (DCD) 是糖尿病的一个重要并发症.
- 食纤维在DCD中的作用及其机制尚未完全理解.
研究的目的:
- 研究糖尿病患者的食纤维摄入量和认知表现之间的关联.
- 用小鼠模型探索食纤维对DCD影响的潜在机制.
主要方法:
- 对2072名糖尿病患者的NHANES数据进行横截面分析.
- 在使用高脂肪饮食的小鼠中诱导DCD,然后补充富可伊丹.
- 对认知功能,神经元形态,肠道微生物群和表观遗传标记 (TET2,SCFA) 的评估.
主要成果:
- 在人类中,饮食纤维摄入量和认知表现之间观察到一种积极的剂量反应关系.
- 富可伊丹补充剂恢复了DCD小鼠的认知功能和神经元形态.
- 富科伊丹增加了SCFA,增强了TET2稳定性和活性,促进了DNA脱甲基化.
结论:
- 饮食纤维摄入量与糖尿病患者的认知功能有积极的相关性.
- 富科伊丹通过调节小鼠中涉及TET2和SCFA的表观遗传机制来预防DCD.
- 这些发现支持食纤维和富可伊丹在管理DCD方面的治疗潜力.
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