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对Mycobacterium caprae的遗传学分析突出了过去和现在在伊比利亚半岛规模的流行病学联系

André C Pereira¹, Bernat Pérez de Val², Mónica V Cunha³

¹cE3c - Centre for Ecology, Evolution and Environmental Changes & CHANGE - Global Change and Sustainability Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Biosystems & Integrative Sciences Institute (BioISI), Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.

Microbes and infection

|August 22, 2024

概括

杆菌 (Mycobacterium caprae) 在山羊中引起广泛的结核病 (TB),并可能传播给人类. 基因组分析揭示了其古老的起源和在欧洲的多个宿主中传播,需要协调的根除努力.

科学领域:

基因组学就是基因组学.
流行病学流行病学
兽医医学兽医医学兽医医学

背景情况:

菌是欧洲山羊结核病 (TB) 的重要原因,导致经济损失和动物传染病.
这种病原体在复杂的多宿主群落中传播,包括食者和野生动物,复杂化了控制工作.

研究的目的:

为了对Mycobacterium caprae进行第一个植物动力学和植物地理学分析.
重建M. caprae.的历史人口结构和传播途径.
调查宿主过渡事件以及M. caprae在欧洲的传播模式.

主要方法:

对来自全球和伊比利亚群体的M. caprae的229个全基因组序列的分析.
对M. caprae进化和传播的植物动力学和植物地理学重建.
基因组流行病学与分子生态学原则的整合.

主要成果:

鉴定出不同的亚洲,中东欧和伊比利亚的M. caprae.
在山羊中,伊比利亚类 (SB0157) 的最近的共同祖先约在100年前.
记录了山羊,野猪和人类之间的频繁宿主过渡,这是由于农业实践和动物贸易所驱动的.
已证明M. caprae在当地和跨国范围内传播,这表明在伊比利亚半岛持续的跨物种传播.

结论:

在欧洲,Mycobacterium caprae具有复杂的进化历史,具有重要的跨物种传播.
动物贸易和混合农业实践促进了M. caprae的传播.
针对山羊的欧盟官方根除计划对于控制多宿主环境中的结核病至关重要.

关键词:

动物结核病动物结核病多主机传输多主机传输这种细菌是Mycobacterium caprae.人类遗传学分析整个基因组测序的测序

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