在自闭症谱系障碍中治疗严重和慢性侵略的高剂量普罗巴诺洛尔:试点,双盲,安慰剂控制,随机交叉研究
Eric B London1, Barbie L Zimmerman-Bier2, J Helen Yoo1
1From the New York State Institute for Basic Research, Department of Psychology, Staten Island, NY.
Journal of clinical psychopharmacology
|August 22, 2024
概括
高剂量普拉诺洛尔有效降低了自闭症谱系障碍 (ASD) 患者的攻击性. 这项试点研究通过远程医疗证明了可行性,并记录了心脏安全性,这表明了有前途的治疗选择.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 自闭症谱系障碍 (ASD) 通常表现为严重的侵略性,难以接受标准治疗.
- 作为β阻塞剂的普罗普拉诺洛尔 (propranolol) 显示出事的前景,但缺乏强有力的临床证据.
- 人们对高剂量普罗兰醇的心血管安全存在担忧.
研究的目的:
- 通过远程医疗评估使用高剂量propranolol治疗ASD攻击性的可行性.
- 在这个人群中评估高剂量propranolol的心脏安全性.
- 提供普拉诺洛尔在降低侵略性方面的初步疗效数据.
主要方法:
- 随机,双盲,安慰剂控制,交叉设计与远程医疗访问.
- 灵活的,分阶段的剂量定位的普拉诺洛尔高达200毫克二次.
- 主要结局:临床整体印象改善 (CGI-I) 和异常行为检查清单-社区易怒 (ABC-C/I).
主要成果:
- 与安慰剂相比,propranolol 阶段显示症状减少了 50% (CGI-I) 和 37% (ABC-I).
- 较大的效果大小 (r = -0.74对于CGI-I, -0.64对于ABC-C/I) 表示显著的疗效.
- 血压保持稳定,霍尔特监视器检查没有显著的结果,表明良好的心脏安全性.
结论:
- 高剂量的普拉诺洛尔在降低ASD患者的侵略性方面似乎有效.
- 远程医疗是进行这种治疗的可行方法.
- 需要进行更大规模的临床试验来证实这些发现.
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