口服与注射:哪种维生素D增强剂对低水平最有效?
Neha Agarwal1, Pallavi Lohani2, Shruti Singh1
1Department of Pharmacology, 442340 All India Institute of Medical Sciences Patna , Patna, India.
Journal of basic and clinical physiology and pharmacology
|August 22, 2024
概括
每月肌肉内注射维生素D最有效地达到最佳水平,与每日片或每周小包相比,显著增加了充足度. 这种途径确保了更好的骨和矿物质健康结果.
科学领域:
- 内分泌学和新陈代谢学
- 营养科学 营养科学
- 骨健康研究 骨健康研究
背景情况:
- 维生素D对于骨和矿物质平衡至关重要.
- 维持足够的维生素D水平 (≥30 ng/mL) 对整体健康至关重要.
- 低于最佳的维生素D水平是一个广泛关注的问题,需要有效的补充策略.
研究的目的:
- 为了比较不同维生素D补充路线的疗效.
- 确定实现和维持维生素D充足度 (≥30 ng/mL) 的最佳途径.
- 通过有效的维生素D补充来支持骨和矿物质健康.
主要方法:
- 一个开放的随机试验,涉及132名参与者 (18-60岁) 的维生素D水平较低.
- 三组接受:每日口服片 (800 IU),每周口服袋 (60,000 IU) 或每月肌内注射 (300,000 IU).
- 在6周和12周测量血清维生素D水平.
主要成果:
- 每月肌肉内注射组在6周和12周显示出持续较高的维生素D平均水平.
- 维生素D缺乏症显著降低,在每月IM组12周内达到100%的充分性.
- 与口服方法相比,每月的IM途径在提高维生素D水平方面表现优越.
结论:
- 每月肌肉内注射维生素D是非常有效的,以实现充足.
- 与每天或每周口服相比,这种途径为维生素D补充提供了优越的策略.
- 这些发现支持每月进行内脏注射以优化维生素D状态和骨健康.
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